|
KMID : 0648420110160010031
|
|
Journal of Korean Society of Pediatric Endocrinology
2011 Volume.16 No. 1 p.31 ~ p.37
|
|
|
Evaluation of Growth Status Using Serum IGF-I and IGFBP-3 in Children with Subclinical Hypothyroidism
|
|
Bae Jae-Wook
Kwak Byung-Ok
Chung So-Chung
|
|
|
Abstract
|
|
|
Purpose: The aim of this study was to evaluate growth status using the insulin-like growth factor-I (IGF-I) and
IGF-binding protein-3 (IGFBP-3) concentrations in children with subclinical hypothyroidism (SCH).
Methods: The study included 93 SCH patients (33 males and 60 females, age 8.1±1.9 years) and 94 healthy
control subjects (31 males and 63 females, age 8.0±0.7 years). Patients’ height and weight were measured, and
their body mass index (BMI) and Z-scores were calculated. The relationship between growth parameters, including
IGF-I and IGFBP-3 concentrations and thyroid functions (thyroid-stimulating hormone (TSH) and free thyroxine 4
(fT4) was explored.
Results: Although weight and BMI were greater in SCH patients, the Z-score of height, weight and BMI, and serum IGF-I and IGFBP-3 levels in SCH children were not significantly different compared to the control. In SCH patients,
TSH showed a negative correlation with weight Z-scores (r =-0.23, P =0.028) and BMI Z-scores (r =-0.21, P =0.048).
FT4 showed a positive correlation with IGFBP-3.
Conclusion: The positive correlation of fT4 and IGFBP-3 and the negative relationship between TSH and weight
and BMI Z-scores in SCH children suggest that subnormal thyroid functions could be related to growth impairment.
|
|
|
KEYWORD
|
|
|
Hypothyroidism, Growth, Child
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|